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  基本信息
  • 姓      名:王宇
  • 职      称:教授
  • 职      位:
  • 所  属 系:
  • 办公地点:丽湖校区守慧楼(A6)-307室
  • 办公电话:
  • 邮      箱:yu-wang@szu.edu.cn
  • 工作职责:
  个人简介
王宇,深圳大学特聘教授,博士生导师,入选中国科学院和深圳市高层次人才计划。1999-2004年,中国科学技术大学本科;2004-2010年,哈佛大学(Harvard University)博士研究生,师从Andrew P. McMahon院士;2010-2011年,哈佛大学博士后(Postdoctoral Fellow),师从Andrew P. McMahon院士和Lee L. Rubin教授;2011-2014年,威斯康星大学麦迪逊分校(University of Wisconsin at Madison)莫格利奇研究院(Morgridge Institute for Research)助理研究员/访问学者(Research Associate/Visiting Scholar),师从James A. Thomson院士;2013-2020年,中国科学院动物研究所研究员(Professor/Principle Investigator)、中国科学院大学医学院岗位教授(Adjunct Professor),2020-今,深圳大学特聘教授(Distinguished Professor),药物调控合成生物学研究中心(筹)主任(Director, Research Center of Pharmacological Synthetic Biology)。主持和参加科技部国家重大科学研究计划、国家自然科学基金委重大培育项目等7项国家和省部级项目。应邀为Elife、Cell Chemical Biology等国际重要学术期刊撰写点评和综述。应邀为Advanced Science、Protein &Cell等国际重要学术期刊审稿。迄今发表二十余篇国际学术论文,引用超过1000次。近年来,以通讯作者带领团队在Nucleic Acids Research、Cancer Research、Cell Chemical Biology、Elife、Molecular Therapy-Nucleic Acids等国际重要学术期刊发表多篇论文。
王宇课题组面向癌症和退行性疾病的共性机制以及COVID-19,专注于药物发现和药物调控合成生物学两个方向的科学研究和转化应用。研究方向包括:1)药物和药靶的高通量筛选;2)基因编辑技术的改进和新颖应用方式的开发。
  近期发表的论文

近期发表论文(* 通讯作者;1第一作者。)

1. Prostaglandin E1 Inhibits GLI2 Amplification-Associated Activation of the Hedgehog Pathway and Drug Refractory Tumor Growth. Wu, F, Zhang, C. Zhao, C., Wu, H., Jiang, T. *, Wang, Y.*(2020) Cancer Research 80(13):2818-2832. (Impact Factor) (IF=12.7012020).

2. Wang, X.1, Liao, T. 1, Wan, C., Yang, X., Zhao, J., Fu, R., Yao, Z., Huang, Y., Shi, Y., Chang, G., Zheng, Y., Luo, F., Liu, Z., Wang, Y.*, Mao, X.*, Zhao, XY.* (2019) Efficient generation of human primordial germ cell-like cells from pluripotent stem cells in a methylcellulose-based 3D system at large scale. Peer Journal 6:e6143.IF=2.984).

3. Zhang, J*1., Chen, L1., Zhang J1., Wang, Y.* (2019) Drug inducible CRISPR/Cas systems. Computational and Structural Biotechnology Journal 17:1171-1177. (Invited review). (IF=7.271).

4. Zhao, C*1., Wei, S., Wang, Y.* (2019) A guide for drug inducible genome editing with HIT systems. Methods in Enzymology 621:53-68. (Invited protocol). (IF=1.600).

5. Zhao, C*1., Wei, S., Wang, Y.* (2019) A guide for drug inducible transcriptional activation with HIT systems. Methods in Enzymology 621:69-86. (Invited protocol). (IF=1.600).

6. Xu, J. 1, Yu, L., Guo, J., Xiang, J., Zheng, Z., Gao, D., Shi, B., Hao, H., Jiao, D., Zhong, L., Wang, Y., Wu, J. *, Wei, H. *, Han, J. * (2019) Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system. Stem Cell Research & Therapy 10(1):193. (IF=6.832).

7. Lu, J1., Zhao, C1., Zhao, Y1., Zhang, J1., Zhang, Y., Chen, L., Han, Q., Ying, Y., Peng, S., Ai, R., Wang, Y.* (2018) Multimode drug inducible CRISPR/Cas9 devices for transcriptional activation and genome editing. Nucleic Acids Research 46(5): e25. (IF=16.971) .

8. Zhao, C1., Zhao, Y1. Zhang, J1.,Lu, J., Chen, L., Zhang, Y., Ying, Y., Xu, J., Wang, Y.* (2018) HIT-Cas9: a CRISPR/Cas9 genome editing device under tight and effective drug control. Molecular Therapy-Nucleic Acids 1(13): 208-219. (IF=8.886) .

9. Zhao, C1., Zhang, Y1., Zhao, Y., Ying, Y., Ai, R., Zhang, J., Wang, Y.* (2018) Multiple chemical inducible Tal effectors for genome editing and transcription activation. ACS Chemical Biology 13(3): 609-617. (IF =5.100).

10. Wu, F1., Zhang, Y., Sun, B., McMahon, A.P., Wang, Y.* (2017) Hedgehog signaling: from basic biology to cancer therapy. Cell Chemical Biology 24 (3): 252-280. (Invited review) (IF=8.116SCI高被引论文)

11. Liu, L. 1, Zhang, J. 1, Rheindt, F.E. 1, Lei, F., Qu, Y., Wang, Y., Zhang, Y., Sullivan, C., Nie, W., Wang, J., Yang, F., Chen, J., Edwards, S.V. *, Meng, J., Wu, S. *, (2017) Genomic evidence reveals a radiation of placental mammals uninterrupted by the KPg boundary. PNAS 114 (35):E7282-E7290. (IF =11.205).

12. Liu, L. 1, Zhang, J. 1, Rheindt, F.E. 1, Lei, F., Qu, Y., Wang, Y., Zhang, Y., Sullivan, C., Nie, W., Wang, J., Yang, F., Chen, J., Edwards, S.V. *, Meng, J., Wu, S. *, (2017) Reply to Gatesy and Springer: Claims of homology errors and zombie lineages do not compromise the dating of placental diversification. PNAS 114 (45):E9433-E9434. (IF =11.205).

13. Li, Y. 1, Zhang, W. 1, Chang, L. 1, Han, Y., Sun, L., Gong, X., Tang, H., Liu, Z., Deng, H., Ye, Y., Wang, Y., Li, J., Qiao, J., Qu, J. *, Zhang, W. *, Liu, G.H. *, (2016) Vitamin C alleviates aging defects in a stem cell model for Werner syndrome. Protein & Cell 7(7):478-488. (IF =14.870).

14. Ding, H. 1, Yang, D., Zhao, C., Song, Z., Liu, P., Wang, Y., Chen, Z. *, Shen, J. (2015) Protein-gold hybrid nanocubes for cell imaging and drug delivery. ACS Appl. Mater. Interfaces 7 (8): 4713–4719. (IF =9.229).

15. Schwartz, M.P. 1, Hou, Z. 1, Propson, N.E., Zhang, J., Engstrom, C.J., Costa, V.S., Jiang, P., Nguyen, B.K., Bolin, J.M., Daly, W., Wang, Y., Stewart, R., Page, C.D., Murphy, W.L., Thomson, J.A. * (2015) Human pluripotent stem cell-derived neural constructs for predicting neural toxicity. PNAS 112 (40): 12516-12521. (IF =11.205SCI高被引论文)

16. Wang, Y. 1*, and McMahon, A.P. (2013). A novel site comes into sight. eLife 2, e01680. (Invited commentary). (IF =8.140).

17. Wang, Y. 1, Davidow, L., Arvanites, A.C., Blanchard, J., Lam, K., Xu, K., Oza, V., Yoo, J.W., Ng, J.M., Curran, T., Rubin, L.L. *, McMahon, A.P*. (2012). Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity. Chemistry & Biology (currently renamed to Cell Chemical Biology) 19, 972-982. (IF =8.116).

18. Wang, Y. 1, Arvanites, A.C., Davidow, L., Blanchard, J., Lam, K., Yoo, J.W., Coy, S., Rubin, L.L. *, McMahon, A.P*. (2012). Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation. ACS Chemical Biology 7, 1040-1048. (IF =5.100).

19. Wang, Y. 1, Zhou, Z., Walsh, C.T. *, McMahon, A.P. * (2009). Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation. PNAS 106, 2623-2628. (IF =11.205).

20. Zhou, Z.1, Koglin, A., Wang, Y., McMahon, A.P., Walsh, C.T.*. (2008) An eight residue fragment of an acyl carrier protein suffices for post-translational introduction of fluorescent pantetheinyl arms in protein modification in vitro and in vivo. Journal of the American Chemical Society 130(30):9925-30. (IF =15.419).

21. Wang, Y.1, McMahon, A.P. *, Allen, B.L. 1 (2007). Shifting paradigms in Hedgehog signaling. Current Opinion in Cell Biology 19, 159-165. (IF =8.382).




职称 教授 职位
所属系 办公室 丽湖校区守慧楼(A6)-307室
办公电话 邮箱 yu-wang@szu.edu.cn
工作职责 个人简介 王宇,深圳大学特聘教授,博士生导师,入选中国科学院和深圳市高层次人才计划。1999-2004年,中国科学技术大学本科;2004-2010年,哈佛大学(Harvard University)博士研究生,师从Andrew P. McMahon院士;2010-2011年,哈佛大学博士后(Postdoctoral Fellow),师从Andrew P. McMahon院士和Lee L. Rubin教授;2011-2014年,威斯康星大学麦迪逊分校(University of Wisconsin at Madison)莫格利奇研究院(Morgridge Institute for Research)助理研究员/访问学者(Research Associate/Visiting Scholar),师从James A. Thomson院士;2013-2020年,中国科学院动物研究所研究员(Professor/Principle Investigator)、中国科学院大学医学院岗位教授(Adjunct Professor),2020-今,深圳大学特聘教授(Distinguished Professor),药物调控合成生物学研究中心(筹)主任(Director, Research Center of Pharmacological Synthetic Biology)。主持和参加科技部国家重大科学研究计划、国家自然科学基金委重大培育项目等7项国家和省部级项目。应邀为Elife、Cell Chemical Biology等国际重要学术期刊撰写点评和综述。应邀为Advanced Science、Protein &Cell等国际重要学术期刊审稿。迄今发表二十余篇国际学术论文,引用超过1000次。近年来,以通讯作者带领团队在Nucleic Acids Research、Cancer Research、Cell Chemical Biology、Elife、Molecular Therapy-Nucleic Acids等国际重要学术期刊发表多篇论文。

王宇课题组面向癌症和退行性疾病的共性机制以及COVID-19,专注于药物发现和药物调控合成生物学两个方向的科学研究和转化应用。研究方向包括:1)药物和药靶的高通量筛选;2)基因编辑技术的改进和新颖应用方式的开发。